The relationship between the level of CTEN and recurrence, metastasis and prognosis of colorectal carcinoma patients after operation

Objective:To investigate the relationship between the levels of COOH-terminus tensin-like molecule(CTEN) and recurrence,metastasis and prognosis of colorectal carcinoma patients after operation.Methods:The expression levels of CTEN in colorectal carcinoma tissue of 80 patients were detected using immunohistochemistry(IHC),and the relation of which with prognosis was analyzed.Results:The positive rates of CTEN in colorectal carcinoma tissue and paracarcinoma tissues were 83.8%(67/80) and 12.5%(10/80),respectively,the difference of which was statistical significance(P<0.05).The positive rates of CTEN in stages Ⅲ and Ⅳ patients were significantly higher than that in stages Ⅰ and Ⅱ patients(P<0.05).The positive rates of CTEN in recurrence and metastases patients after 3 years of operation were higher than that in no-recurrence and metastases patients(P<0.01).Kaplan-Meier survival analysis showed that the prognosis in no and low expression of CTEN patients were significantly better than that in high expression of CTEN patients(P<0.01).Conclusions:The expression of CTEN is correlation with the postoperative recurrence and metastases of patients with colorectal carcinoma,which may be an effective predictor in the prognosis of colorectal carcinoma.