The expressions and significance of kinase domain receptor,melanocortin-2 receptor and proliferating cell nuclear antigen in aldosterone-producing adenoma and adrenal cortical hyperplasia

Objective:To explore the expressions and significance of kinase domain receptor(KDR), melanocortin-2 receptor(MC2R) and proliferating cell nuclear antigen(PCNA) in aldosterone-producing adenoma(APA) and adrenal cortical hyperplasia(IHA).Methods:The expressions of KDR, MC2R and PCNA in 40 cases APA and 40 cases IHA lesions were detected by immunohistochemistry.Results:The positive expression rates of KDR, MC2R and PCNA in APA lesions were 40.0%, 32.5% and 85.0%, respectively.The expression rates of KDR, MC2R and PCNA in IHA lesions were 65.0%, 62.5% and 77.5%, respectively.The differences of KDR, MC2R and PCNA expressions between APA and IHA were statistically significant(P<0.05 to P<0.01).Conclusions:The KDR, MC2R and PCNA play an important role in the occurrence and development of IHA, which have important reference meaning in the differentiation of APA and IHA lesions.