Correlation analysis between the cognitive dysfunction and event-related potential mismatch negativity in patients with cerebral infarction

Objective: To investigate the correlation between the cognitive dysfunction and event-related potential(ERP) in patients with cerebral infarction. Methods: Forty-three paitents with symptomatic cerebral infarction, 43 patients with asymptomatic cerebral infarction and 43 heathy people were divided into the SCI group, ACI group and control group, respectively. The cognitive function in 3 groups were evaluated using Montreal Assessment Scale Beijing edition(MoCA), and 2 kinds of ERP, N400 and mismatch negativity(MMN) in 3 groups were detected using evoked potential detector, the correlations of MMN, N400 and MoCA score were analyzed, and the MMN and N400 in different parts of cerebral infarction were compared. Results: The MoCA scores in ACI group and SCI group were significantly lower than that in control group, and the MoCA score in SCI group was lower than that in ACI group. Compared with the control group, the extending latency and decreasing amplitude of MMN and N400 in SCI group and ACI group were found(P<0.01). The latency of MMN and N400 and amplitude of N400 in SCI group were higher and lower than those in ACI group, respectively(P<0.01 and P<0.05). The latency of MMN and N400 were negative correlation with MoCA score, the amplitude of MMN and N400 were postive correlation with MoCA score. The latency and amplitude of MMN and N400 in posterior circulation infarction patients were significantly higher and lower than those in the anterior circulation infarction patients, respectively(P<0.01). Conclusions: Patients with symptomatic or asymptomatic cerebral infarction have cognitive dysfunction, which can be early detected using ERP, and MMN has a higher correlation with cognitive dysfunction.