Effect of reduced glutathione on AECOPD therapy

Objective:To investigate the effects of reduced glutathione on acute exacerbation of chronic obstructive pulmonary disease(AECOPD) therapy.Methods:Seventy AECOPD patients were randomly divided into the control group and observation group(35 cases each group).The levels of 8-iso-prostaglandin-F_2α(8-iso-PGF_2α) and C reactive protein(CRP), pulmonary function and blood gas analysis in two groups were detected at the time of admission.Two groups were treated with conventional anti-inflammatory, expectorant and antiasthmatic for 1week, the observation group were additionally treated with reduced glutathione for 1 week.The levels of 8-iso-prostaglandin-F_2α and CRP, pulmonary function and blood gas analysis in two groups were detected again after 1 week of treatment, and statistically analyzed.Results:Compared with pre-treatment, the levels of 8-iso-PGF_2α and CRP in two groups decreased significantly after 1 week of treatment(P<0.01), the levels of 8-iso-PGF_2α and CRP in observation group were significantly lower than those in control group(P<0.01).Compared with pre-treatment, the indexes of pulmonary function and blood gas analysis in two groups were significantly improved after treatment, the improvement degree in observation group were significantly better than those in control group(P<0.01).Conclusions:Reduced glutathione can alleviate the oxidative stress response in patients with AECOPD, which has a certain adjuvant therapy value.