Meta-analysis of total glucosides paeony combined with methorexate in the treatment of rheumatoid arthritis

Objective:To analyze the clinical efficacy of total glucosides paeony(TGP) combined with methorexate(MTX) in treatment of rheumatoid arthritis.Methods:Randomized controlled trials about the effect of TGP combined with MTX on patients were collected by searching PubMed, China National Knowledge Infrastructure, China Biology Medicine disc and Wan Fang Database.The quality of included studies was assessed according to the criteria recommended Cochrane Collaboration, Meta-analysis was performed using RevMan5.3 software.Results:Ten randomized controlled trials involving 867 patients were included, 484 in experimental group, and 383 in control group.Meta-analysis results were shown that the effective rate of experimental group was better than that of control group after 12 and 24 weeks(P<0.01).Nevertheless, there were no statistical significance about the effective rate between experimental group and control group after 4 and 8 weeks(P>0.05).Conclusions:TGP combined with MTX in the treatment of rheumatoid arthritis is much better than MTX alone in total effective rate.