Analysis of the influencing factor on the severity of coronary artery disease

Objective:To investigate the influencing factors of the severity of coronary artery disease(CAD).Methods:Two hundred and sixty-five CAD patients and 64 normal people diagnosed by coronary angiography were invetigated.The risk factors of coronary disease, included male, age, hypertension, diabetes mellitus, hyperlipemia, lower serum high density lipoprotein cholesterol(HDL-C), hyperuricemia, family history and smoking, were recorded.The severity of CAD, number of disease vessels and scores of Gensini were determined by coronary angiography.The relationship between risk factor and severity of CAD was analyzed using the univariate analysis and multivariate logistic regression.Results:The univariate analysis showed that the age, male, hypertension, diabetes mellitus, smoking and lower HDL-C were associated with the severity of CAD, the age, fasting blood glucose, serum uric acid, LDL-C were postive correlation with Gensini scores(P<0.05 to P<0.01), the HDL-C was negatively correlated to Gensini scores(P<0.05), and the age, systolic pressure and serum uric acid were postively correlated to the number of diseased vessels(P<0.05 to P<0.01).Multivariate linear regression analysis showed that male was the most risk factor in severity of CAD, and followed by age, hypertension and diabetes mellitus(standandized coefficients B for 0.279, 0.189, 0.164 and 0.116, respectively).Logistic regression analysis showed that the age, male, hypertension and diabetes mellitus were the independent risk factors for CAD, and the Odds Ratio(OR) value of diabetes mellitus and male were higher(OR=5.789 and OR=5.516), followed by hypertension(OR=2.407) and age(OR=2.093)(P<0.05 to P<0.01).Conclusions:The age, male, hypertension, diabetes mellitus are the main influencing factors on CAD, and the hypertension and diabetes mellitus should be prevented and controled.