The resistant characteristics and sensitivity analysis of ESBLs Escherichia coli produced by urine culture

Objective:To analyze the resistant characteristics of ESBLs Escherichia coli produced by urine culture, investigate its antibacterial activity in vitro and compare with other antibacterial drugs.Methods:A total of 821 strains were cultured from the strain library, the ESBLs Escherichia coli produced by urine culture were screened according to the phenotype of ESBLs, the antibacterial activities in vitro of 15 antimicrobial agents, including fosfomycin, were detected by K-B method.Results:Among the 821Escherichia coli strains, the sensitivities of the 465 ESBLs Escherichia coli strains produced by urine culture to imipenem were high(91.4%), following by fosfomycin(88.0%), the sensitivities of which to levofloxacin, penicillin and cephalosporin were low.Conclusions:The sensitivity of carbapenem is the highest drug, the antibacterial activity in vitro of fosfomycin to ESBLs Escherichia coli produced by urine culture is good, which has certain clinical value.