The risk factors analysis of acute exacerbation of chronic obstructive pulmonary disease patients complicated with ventilator-associated pneumonia

Objective: To investigate the risk factors of acute exacerbation of chronic obstructive pulmonary disease(AECOPD) patients complicated with ventilator-associated pneumonia(VAP), and provide the basis for the clinical treatment of patients with AECOPD. Methods: The clinical data about the relationships of the occurrence of VAP and the general information (age, gender and body mass index), nutrition support route (enteral nutrition or total parenteral nutrition support), whether application of acid suppressive drugs, whether complicated with basic diseases, mechanical ventilation time in the 104 AECOPD patients were analyzed retrospectively. Results: The incidence of VAP was increased by total parenteral nutrition and combined with basic diseases(P<0.05 and P<0.01). There was no significant difference between the incidence of VAP and gender, age, body mass index, the application of acid suppressive drugs and the time of ventilator ventilation(P>0.05). The results of logistic regression analysis were shown that the total parenteral nutrition support and combination with basic diseases were the independent risk factors for VAP (P<0.05). Conclusions: There are many factors affecting the incidence of VAP in AECOPD patients, the basic diseases should be treated actively, and early enteral nutrition support should be done, to improve the prognosis of patients.