Clinical effect of fasudil in the treatment of interstitial lung disease associated with connective tissue disease

Objective: To observe the clinical effects of fasudil in the treatment of interstitial lung disease associated with connective tissue disease.Methods: Sixty-two patients with interstitial lung disease associated with connective tissue disease were randomly divided into the control group(32 cases) and treatment group(30 cases).The control group were treated with conventional measures,and the treatment group were additionally treated with 30 mg fasudil based on the control group for 14 days.The 6-min walk test,pulmonary arterial pressure measured by echocardiography,high chest resolution CT and blood gas analysis and erythrocyte sedimentation rate and C reactive protein before and after treatment were compared.Results: After treatment,the 6-min walk distance increased,pulmonary artery pressure dropped,high resolution chest CT score decreased and activity reduced.The differences of whose between treatment groupbeforeand after treatment,and control group were statistically significant(P < 0.01).Conclusions: The treatment of interstitial lung disease associated with connective tissue disease with fasudilis effective.