The correlations between the degree of coronary lesion and levels of serum uric acid, brain natriuretic peptide and high sensitivity C reactive protein in patients with coronary artery disease

Objective: To investigate the correlations between the degree of coronary lesion and levels of serum uric acid(UA),brain natriuretic peptide(BNP) and high sensitivity C-reactive protein(hs-CRP) in patients with coronary artery disease(CHD).Methods: The coronary angiography in 72 suspect CHD cases were examined,and 52 pateints with CHD were diagnosed.The 52 CHD patients were divided into the acute myocardial infarction group(AMI group,23 cases) and unstable angina pectoris group(UAP group,29 cases).The AMI group with thrombolytic therapy indication and without contraindication were treated with intravenous urokinase.Fifty-two CHD cases were divided into the one-vessel disease group(18 cases),two-vessel disease group(19 cases) and multiple-vessel disease group(15 cases) according to the lesion degree detected by coronary angiography.The 20 cases without CHD were set as the control group.The serum levels of UA,BNP and hs-CRP in different groups were compared.Results: The serum levels of UA,BNP and hs-CRP in AMI group were significantly higher than those in UAP group and control group(P<0.05 to P<0.01).The serum levels of UA and BNP in UAP group were significantly higher than those in control group(P<0.01).The serum levels of UA,BNP and hs-CRP in two- and multiple-vessel disease groups were obviously higher than those in one-vessel disease group(P<0.01),the serum levels of UA,BNP and hs-CRP in multiple-vessel disease group were higher than those in two-vessel disease group(P<0.05 to P<0.01).Conclusions: The serum levels of UA,BNP and hs-CRP have certain correlations with the lesion degree of coronary in CHD patients,and those indexes can be used to evaluate the degree of myocardial ischemia,and acted as the indexes of risk stratification.