Correlation analysis of plasma homocysteine level with acute cerebral infarction

Objective: To explore the relationship between the plasma homocysteine(Hcy) level and acute cerebral infarction,and its correlation with plasma folic acid and vitamin B₁₂.Methods: One hundred and twenty patients with acute cerebral infarction diagnosed by head CT or MRI and 98 healthy people were divided into the acute cerebral infarction group and control group,respectively.The levels of plasma homocysteine,and plasma folic acid and vitamin B₁₂ in two groups were measured by fluorescence polarization immunoassay(FPLA) and electrochemical luminescence immunoassay(ECLI),respectively.Results: The levels of plasma homocysteine,plasma folic acid and vitamin B₁₂ in acute cerebral infarction group were significantly higher than those in control group(P<0.01).The folic acid and vitamin B₁₂ levels of acute cerebral infarction group were significantly lower than those in confrol group(P<0.01).The level of plasma homocysteine was negative correlation with the levels of plasma folic acid and vitamin B₁₂ in acute cerebral infarction group(P<0.05).Conclusions: The hyperhomocysteinemia is an independent risk factor of acute cerebral infarction.Supplementing the folic acid and vitamin B₁₂ can reduce the serum homocysteine,which can reduce the incidence of cerebral infarction.