Effect of light sedation induced by midazolam on cough induced by fentanyl

Objective: To investigate the effects of the light sedation induced by low dose midazolam on cough induced by fentanyl.Methods: Sixty patients scheduled by general anesthesia operation were divided into the control group and midazolam group using a random number table(30 cases each group).The midazolam group were intravenously injected with 0.03 mg/kg(1 mg/mL) of midazolam.The control group were intravenously injected with equal amount of 0.9% sodium chloride injection for 3 s,and the 3 μg/kg(50 μg/mL) of fentanyl was used for 3 s after 120 s.The occurrence rate and degree of cough,the anesthesia/awareness depth and modified OAA/S score at the time of using fentanyl were recorded after 120 s of treatment.Results: Compared with the control group,the incidence and severity of cough significantly increased in midazolam group(P<0.01),the value of the depth of anesthesia/consciousness significantly decreased in midazolam group,which arrived at light sedation(P<0.01).The score of modified OAA/S in midazolam group was more than or equal to 4 points after the intravenous injection of fentanyl.Conclusions: At the time of light sedation induced by a low dose of midazolam,the incidence and severity of cough caused by intravenous injection fentanyl increase.