Expression of P27 in different types of glandularis cystitis and its clinical significance

Objective: To analyze the expressions of P27 in different clinical and pathological type of glandularis cystitis,and provide the basis in judging the malignant change of different types of glandularis cystitis.Methods: Eighty-five patients with glandularis cystitis were divided into the different clinical and pathological type,25 normal bladder mucosa tissues were set as the control.The P27 expressions in glandularis cystitis tissue and normal bladder mucosa tissue were detected by immunohistocemistry S-P method,the result of which was analyzed using the automatic microscope and image analysis system.Results: Among the different clinical types of glandularis cystitis tissue,the positive expressions of P27 in nipple and intestinal adenoma type cystitis were significantly lower than that in normal bladder mucosa tissue(P<0.01).However,the differences of the positive expressions of P27 between chronic inflammatory type,follicular type and normal bladder mucosa tissue were not statistically significant(P>0.05).Among the different pathological types of glandularis cystitis tissue,the positive expressions of P27 in intestinal epithelial and prostatic intraepithelial neoplasia type cystitis were significantly lower than that in normal bladder mucosa tissue(P<0.01).However,the difference of the positive expression of P27 between transitional type and normal bladder mucosa tissue was not statistically significant(P>0.05).Conclusions: In the clinical type,the nipple and intestinal type glandularis cystitis may be precancerous lesion.In the pathological type,the intestinal epithelial and prostate epithelial type of glandularis cystitis may be precancerous lesion.The cancer possibility in patient with nipple and intestinal adenoma type of gladnularis cystitis complicated with intestinal metaplasia of prostate epithelial metaplasia is large,and the patient should be treated with positive operation,bladder instillation and close following-up.