Effect of dexmedetomidine on the levels of S100β protein and neuron specific enolase in removal of intracranial hematoma patients

Objective: To investigate the effects of dexmedetomidine on the levels of S100β protein and neuron specific enolase(NSE) in removal of intracranial hematoma patients.Methods: Forty patients scheduled by removal of intracranial hematoma were randomly divided into the dexmedetomidine group(group D) and control group(group C)(20 cases each group).In group D,the 10 mL/h(4 μg/mL) of dexmedetomidine was continuously infused by pump before 10 min of anesthesia,and stopped until the end of operation,and then the 2 mL/h(6 μg/mL) of dexmedetomidine was infused by vein for 48 h after the surgery.In group C the same volume of saline was infused.The anesthesia method,induction and maintenance in two groups were the same.The levels of S100β protein and neuron specific enolase before the dexmedetomidine infusing(T₀),the end of operation(T₁),and after 6 h(T₂),12 h(T₃),24 h(T₄),36 h(T₅) and 48 h(T₆) of operation in two groups were detected by ELISA.Results: Compared with the T₀,the levels of plasma S100β protein and NSE in group D decreased significantly from T₁ to T₆(P<0.01),the differences of the plasma S100β protein in group C from T₁ to T₆ were not statistically significant(P>0.05),but the levels of NSE in group C from T₂ to T₆ increased significantly(P<0.01).The levels of S100β protein and NSE in group D from T₁ to T₆ were significantly lower than those in group C(P<0.01).Conclusions: The dexmedetomidine can effectively reduce the levels of the S100β protein,and alleviate the brain injury in removal of intracranial hematoma patients