The correlation study between the levels of serum uric acid and brain natriuretic peptide in patients with progressive ischemic stroke

Objective: To investigate the relationship between the levels of serum uric acid(UA) and N-terminal pro-brain natriuretic peptide(NT-proBNP) in patients with progressive ischemic stroke(PIS).Methods: The serum levels of UA and NT-proBNP in PIS patients(34 cases,PIS group) and Non-PIS patients(30 cases,NPIS group) were determined.The PIS group were subdivided into the light group,medium group and heavy group according to the score of National Institute of Health Stroke Scale(NIHSS).The PIS group were subdivided into the small lesion group,medium lesion group and large lesion group according to the results of the CT/MRI examination.The levels of UA and NT-proBNP between all groups were compared.Results: The levels of UA and NT-proBNP in PSI group were significantly higher than those in NPSI group(P<0.01).With the increasing of the score of NIHSS in PIS group,the levels of UA and NT-proBNP gradually increased in light,medium and heavy patients(P<0.05 to P<0.01),and with the increasing of the volume of lesion in PIS group,the levels of UA and NT-proBNP gradually increased in small,medium and large lesion patients(P<0.01).Conclusions: The levels of UA and NT-proBNP can reflect the progress and infarct size of ischemic stroke,which has important significance in the diagnosis and treatment of PIS.