Efficacy of the pegylated interferon combined with ribavirin in the treatment of different virus genotype chronic hepatitis C

Objective: To observe the clinical effects of pegylated interferon(PegIFN) combined with ribaririn in the treatment of chronic hepatitis C.Methods: Eighty hepatitis C patients were divided into the hepatitis C virus(HCV)lb group and non-HCV 1b group according to the genotype of HCV.The two groups were treated with PegIFN(1.5 μg/kg) by subcutaneous injection combined with ribavirin by oral.The HCV ribonucleic acid(RNA) in two groups were detected before and after treatment.The rates of sustained virological response in two groups were compared.Results: The rates of sustained virological response in HCV lb group and non-HCV 1b group were 58.1% and 86.5%,the difference of which was statistically significant(P<0.01).Conclusions: The effect of Peg-interferon combined with ribavirin in treating HCV 1b is unsatisfactory,and the treatment effect of HCV is closely related to the genotype of HCV.