Effect of laparoscopic cholecystectomy on immune function,stress and liver function in patients

Objective: To explore the effect of laparoscopic cholecystectomy on the immune function,stress and liver function in patients.Methods: One hundred sixty-eight cases of benign lesions of gallbladder in the Department of hepatobiliary surgery of our hospital were selected,divided into 113 cases of laparoscopic cholecystectomy group,55 cases of open cholecystectomy group,early morning fasting venous blood were taken 1d before the operation,1 d,3d and 9d after the operation to detect the immune function,stress and liver function.Results: CD3⁺,CD4⁺,IgG,IgM,IgA were all decreased 1d after the operation,3 d after the operation began to increase,and 9 d all recovered to 1 d before the operation,CD8⁺ was increased 1d after the operation,3 d was reduced,and 9 d was restored to 1 d before the operation;CD3⁺,CD4⁺,IgG,IgM in laparoscopic cholecystectomy group reducted less than open cholecystectomy group 1d after the operation(P<0.05),increased higher than open cholecystectomy group 3d after the operation(P<0.05),The reduction rate of CD8⁺ was higher than that in open cholecystectomy group 3 d after the operation(P<0.05),the increase IgA was higher than that in open cholecystectomy group 3d after the operation(P<0.05).Stress indexes IL-6,TNF-αand CRP were all increased 1d after the operation,IL-6,TNF-αwere all decreased 3 d after the operation,only IL-6 recovered to 1d before the operation,TNF-αdecreased after 9 d after the operation;The changes of IL-6,TNF-αand CRP in laparoscopic cholecystectomy group were significantly lower than that in open cholecystectomy group(P<0.01).Liver function indexes ALT,TBIL and AST were all increased 1 d after operation,decreased 3 d after operation,and 9 d recovered to 1d before the operation;The changes of ALT,TBIL and AST in laparoscopic cholecystectomy group were significantly lower than that in open cholecystectomy group(P<0.01).Conclusions: The effect of laparoscopic cholecystectomy on the immune function,stress and liver function of the patients are smaller than that of open cholecystectomy,and it can be the first choice of operation.