Study on drug sensitivity of Pseudomonas aeruginosa L-forms to the third and forth generation cephalosporins

Objective: To study the drug sensitivity of L-forms of Pseudomonas aeruginosa(PA) to the third and forth generation cephalosporins.Methods: PA was induced into a stable L-form.The drug sensitivity of PA L-forms to the third and forth generation cephalosporins was analyzed by K-B drug sensitivity test.The change trend of drug sensitivity and resistance of PA L-forms was analyzed.Results: The inhibition zone of PA L-forms was smaller than that of their parent bacteria,and there had the significant difference(P<0.05).But the drug sensitivity of L-forms of PA to the third and forth generation cephalosporins was still sensitive.Conclusions: The drug sensitivity of PA L-forms to the third and forth generation cephalosporins is still sensitive.