Correlation of plasma enzyme chitin 40 and endothelial microparticle with acute coronary syndrome in elder patients

Objective: To investigate the correlation of the levels of plasma enzyme chitin 40(YKL-40) and endothelial microparticle(EMP) with the acute coronary syndrome(ACS) in elder patients.Methods: A total of 180 patients(≥65 years old) with coronary angiography were randomly divided into the ACS group(96 cases) and control group(84 cases).The serum levels of plasma YKL-40 and EMP in two groups were measured by Enzyme-linked immunosorbent assays and cytometric bead assay technique labeled by CD31⁺/CD42b^-EMPs,respectively.The vascular stenosis degree was quantified by Gensini score.Results: The levels of the YKL-40 and CD31⁺/CD42b^-EMPs in ACS group were significantly higher than those in control group(P<0.01).The Gensini score was significantly positive correlation with the levels of YKL-40 and CD31⁺/CD42b^-EMPs in ACS group(r=0.522,P<0.01;r=0.561,P<0.01).The level of YKL-40 was significantly positive correlation with the level of CD31⁺/CD42b^-EMPs in ACS group(r=0.625,P<0.01).Conclusions: The levels of plasma YKL-40 and CD31⁺/CD42b^-EMPs in ACS patients increase significantly,which is related to the vascular lesion degree.The YKL-40 and EMP maybe a new biochemical marker in diagnosing ACS,which can provide a reference in identifying the severity and risk stratification of coronary artery lesions.