Effect of the systemic chemotherapy combined with transcatheter arterial chemoembolization in the treatment of breast cancer with liver metastasis

Objective: To explore the effects of systemic chemotherapy combined with transcatheter arterial chemoembolization(TACE) in the treatment of breast cancer with hepatic metastasis.Methods: Sixty-eight breast cancer patients with liver metastasis were treated with systemic chemotherapy(32 cases,chemotherapy group),TACE(13 cases,embolism group),and systemic chemotherapy combined with transcatheter arterial chemoembolization(23 cases,combination group).The curative effect,adverse reaction and survival time between three groups were compared.Results: The total effective rate was 41.18%,the effective rates in chemotherapy group,embolism group and combination group were 43.75%,7.69% and 56.52%,respectively.The curative effect in combination group was better than that in embolism group(P<0.01),the difference of the curative effect between the combination group and chemotherapy group was not statistically significant(P>0.05).The median following-up time and survival time in all groups were 18 and 16 months,respectively.The median survival time in chemotherapy group and combination group was 19 months,and the median survival time in embolism group was 13 months,and the differences of the survival time between three groups were statistically significant(P<0.05).The gastrointestinal disorders,bone marrow suppression,hair loss and liver damage were the main adverse reactions in three groups.Conclusions: The treatment of the breast cancer with hepatic metastasis with systemic chemotherapy combined with TACE is good effect and less adverse reaction,which is worth in clinical further promotion.