The application research of anti-cyclic citrullinated peptide antibody in patients with rheumatoid arthritis

Objective: To evaluate the role of anti-cyclic citrullinated peptide(anti-CCP) antibody in the diagnosis of rheumatoid arthritis(RA).Methods: The present study comprised of clinically diagnosed RA patients(RA group),non-RA diseases(control groupⅠ) and healthy subjects(control groupⅡ).To compare the correlation among anti-CCP and rheumatoid factor(RF),they were analyzed by ELISA and immunoturbidimetric assay respectively.Results: The positive rate of anti-CCP antibody was 52.0%,6.0% and 0.0% respectively in RA group,control groupⅠ and control groupⅡ,with significant difference(P<0.01).There was no correlation between anti-CCP antibody and RF(P>0.05).Conclusions: Anti-CCP antibody is a relatively specific diagnosis of RA and the application of anti-CCP antibody in clinic can improve the diagnosis of RA.