Application of oxycodone in diabetics treated with forgetfulness analgesia slow induction by transnasal catheter

Objective: To investigate the effects of intravenous injection of 0.1 mg/kg of oxycodone on the hemodynamics and stress response in diabetics treated with forgetfulness analgesia slow induction by transnasal catheter.Methods: Eighty stage ASA Ⅰ to Ⅱ diabetics(38 to 60 years old) were randomly divided into the oxycodone group(group O) and fentanyl group(group F)(40 cases each group).The group O and group F were treated with 0.1 mg/kg of oxycodone and 1 μg/kg of fentanyl by intravenous injection,respectively.The levels of SBP,DBP,HR,Epinephrine and Norepinephrine in two groups were measured before anesthesia induction(T₀),tracheal tube through choana(T₁),at the time of intubation(T₂),after 3 min of intubation(T₃) and after 10 min of intubation(T₄).Results: Compared before operation,the SBP level in two group increased at T₁ and T₂(P<0.05),and decreased at T₃ and T₄(P<0.05).The increasing degree in group F was higher than that in group O(P<0.05).In group O,the SBP level did not obviously change during operation(P>0.05),and decreased after operation(P<0.05).In F group,the SBP level increased during operation(P<0.05),and decreased after operation(P<0.05).In two groups,the HR level increased during operation(P < 0.05),decreased after operation(P<0.05),and the increasing degree of HR in group F was higher than that in group O(P<0.05).The levels of Epinephrine and Norepinephrine in two group increased after T₂(P<0.05),and the increasing degree of which in group F was higher than that in group O(P<0.05 to P<0.01).Conclusions: The 0.1 mg/kg of oxycodone in diabetics treated with forgetfulness analgesia slow induction by transnasal catheter can maintain the hemodynamic stability,significantly inhibit the stress response of body,and increase the safety of patients with type 2 diabetes during noncardiac surgery.