Effect of ulinastatin on the serum levels of tumor necrosis factor α, interleukin 10,troponin I and C-reactive protein

Objective: To explore the troponin I mechanism of action ulinastatin in sepsis patients by observing the change of cytokine,evaluate the efficacy of ulinastatin and significance of troponin I(cTnI) and C-reactive protein(CRP) in the disease condition and prognosis of sepsis.Methods: Sixty patients with sepsis were selected by the prospective controlled study,and randomly divided into the ulinastatin group(group A) and control group(group B).Based on the same conventional treatment,the group A were treated with 200,000 U ulinastatin by intravenous once 8 hours,and the group B were treated with the same amount of saline.Before treatment and after 48 h and 120 h of treatment,the acute physiology and chronic health evaluation scores(APACHE Ⅱ score) in all patients were investigated,the serum levels of tumor necrosis factor α(TNF-α),interleukin-10(IL-10),CRP and cTnI in two groups were detected,and the 28-day mortality in patients were calculate.Results: The differences of the serum levels of TNF-α,IL-10,cTnI and CRP,and the APACHE Ⅱ score between two groups before treatment were not statistically significant(P>0.05).After 48 h and 120 h of treatment,the levels of TNF-α,CRP and the APACHE Ⅱ score in group A were lower than those in group B(P<0.05 to P<0.01),and the level of IL-10 in group A was significantly higher than that in group B(P<0.01).Compared before treatment,the levels of cTnI and CRP,and the APACHEⅡ score in group A significantly decreased after 48 h and 120 h of treatment(P<0.01).The difference of the 28-day mortality between two groups was not statistically significant(P>0.05).Conclusions: The treatment of sepsis with ulinastatin can not reduce the 28-day mortality,but it can alleviate the inflammatory response,and improve the condition of patients,the mechanism of which may involve in decreasing the level of TNF-α and increasing the level of IL-10.