Effect observation of telbivudine and lamivudine in the treatment of chronic hepatitis B

Objective: To investigate the effects of telbivudine and lamivudine in the treatment of chronic hepatitis B(CHB).Methods: Eighty-two CHB patients were randomly divided into the telbivudine group and lamivudine group(41 cases each group).Telbivudine group and lamivudine group were treated with telbivudine and lamivudine,respectively.The levels of HBV-DNA,HBeAg,AST and ALT in two groups between before and after treatment were compared.The rates of negative-inverted of HBV-DNA and HBeAg and recovery rates of AST and ALT in two groups were compared after 12,24 and 48 weeks of treatment,the safety of which was evaluated.Results: After 12,24 and 48 weeks of treatment,the levels of HBV-DNA,HBeAg,AST and ALT in two groups were significantly lower than before treatment(P<0.01).After 48 weeks of treatment,the rate of negative-inverted of HBV-DNA in telbivudine group was higher than that in lamivudine group(P<0.05).After 24 and 48 weeks of treatment,the recovery rates of AST and ALT in telbivudine group were significantly higher than those in lamivudine group(P<0.05).Conclusions: The treatment of CHB patients with telbivudine is good effect and safety,which is worthy of clinical use.