Effect of the capsule of Linaoxin on the expermiental hypoxia in mice

Objective:To observe the protective effect of the capsule of Linaoxin on the experimental hypoxia in mice.Methods:The effect of the capsule of Linaoxin on the mean survival time and capacity for myocardial oxygen consumption under ordinary or low pressure in mice were observed.Results:Linaoxin capsules in three dosage groups could prolong the survival time of mice under the condition of low pressure and normobaric hypoxia(1-5 min periods)(P < 0.05-P < 0.01);the accumulating time,myocardial oxygen consumption of medication groups under the normal pressure closed condition were obviously reduced (P<0.01),there was significant difference in medication groups(P < 0.05-P < 0.01);the minute net oxygen consumption of the mice in medication groups under the normal pressure closed condition (1-2 min periods) was obviously lowered (P<0.01),there were no significant differences between the medication groups and the control group,significant differences could not be found in the medication groups(P>0.05).Conclusions:The capsule of Linaoxin could evidently reduced capacity for myocardial oxygen consumption and shows a protective role in the hypoxic myocardium in mice.