Study of the correlation between miRNA-182 and BRCA1 mRNA expressions in non-small cell lung cancer

Objective:To compare the difference of the expressions of miRNA-182 and BRCA1 mRNA between non-small cell lung cancer and adjacent normal tissue,and study its correlation.Methods:The expression levels of miRNA-182 and BRCA1 mRNA in 50 non-small cell lung cancer and adjacent tissue specimens were detected using real-time quantitative PCR,the correlation of which was analyzed.Results:The expression levels of miRNA-182 and BRCA1mRNA in cancer tissue were significantly less than those in adjacent tissue(P<0.01),which was not correlated(P>0.05).Conclusions:miRNA-182 and BRCA1mRNA may be related to the occurrence of non-small cell lung cancer,but mutual regulation relation between miRNA-182 and BRCA1 mRNA may not exist.