Comparison of the curative effect of tegafur with XELOX program in the treatment of elderly patients with advanced gastric cancer

Objective:To compare the curative effects and adverse reactions of Tijiao with XELOX program in the treatment of elderly patients with advanced gastric cancer.Methods:Forty-one elderly patients with advanced gastric cancer were randomly divided into the single drug group(20 cases)and combined chemotherapy group(21 cases).The single drug group were treated with the Tijiao by oral,twice a day for 14 days,repeated every 3 weeks(40 mg each time for the body surface area <1.25 m²,50 mg each time for the body surface area between 1.25 m² and 1.5 m² and 60 mg each time for the body surface area >1.5 m²).The combined chemotherapy group were treated with XELOX program,which included the 130 mg/m² of oxaliplatin by intravenous dripat first day for 3 hours combined with 1 000 mg/m² of capecitabineby oral,twice a day for 14 days,repeated every 3 weeks.The curative effects in two groups were evaluated after 2 cycles of treatment.Results:The effective rate,disease control rate and median progression-free(PFS) time in single drug group were 30%,65% and 5.6 months,respectively,the effective rate,disease control rate and median progression-free time in combined chemotherapy group were 42.9%,66.7% and 6.2 months,respectively,and the difference of which between two groupswas not statistically significant(P>0.05).The incidence rate of peripheral neurotoxicity in combined chemotherapy group was higher than that in single drug group(P<0.05),and the incidence of other adverse reactions between two groups was not statistically significant(P>0.05).Conclusions:The short-term curative effect of the Tijiao in treating advanced gastric cancer elderly patients is not worse than that of combination chemotherapy,and which has less adverse reaction.