Clinical and electrophysiological features of Guillain-Barre syndrome and their correlations with prognosis in children

Objective:To study the clinical and electrophysiological features of Guillain-Barre syndrome(GBS),and their correlation with prognosis in children.Methods:The clinical data of sex,age of onset,season of onset,forerunner infection,clinical symptoms and cerebrospinal fluid examination,and electrophysiological result of nerve were retrospectively analyzed in 62 children with GBS.The correlation of the clinical and electrophysiological features with prognosis(at least 1 year after onset) in 40 children with GBS was investigated.Results:Among 62 children with GBS,the ratio of male to female was 2.4 to 1,and the age scope was from 3 months to 15 years old.The 66.1% of cases had definitive inducements,and the most frequent inducement was upper respiratory tract infection(61.3%).The differences in GBS children with different electromyography typing,cranial and autonomic nerves function injury and long-term prognosis were not statistically significant(P>0.05).The Hughes score was more than or equal to at the time of serious condition.The long-term prognosis in GBS children with the involvement of respiratory muscle was worse than that in GBS children with Hughes score <3 or without the involvement of respiratory muscle(P<0.05).The onset age in partial recovery case was significantly more than that in complete recovery case(P<0.01).Conclusions:The GBS child has certain clinical feature,which includes that Hughes score is more than or equal to 3 at the time of serious condition,respiratory muscle is involved,and the high age at onset can result in the imperfect prognosis.