Analysis of the risk factors of epilepsy recurrence after stopping drug in patients treated with monotherapy

Objective:To analyze the epilepsy recurrence within 1 year after stopping drug in complete control patients treated with monotherapy,and high risk factors of inducing relapse.Methods:The drug was stopped in 130 epilepsy patients with monotherapy after the disease was completely controlled.The patients were followed up at least 1 year after stopping drug,and the epilepsy recurrence was recorded.Results:The recurrence rate within 1 year after stopping drug was 40.00%(52/130) in 130 epilepsy patients treated with monotherapy.The univariate analysis showed that the epileptic seizure was more than 5 times 1 year,the duration was more than 1 year before treatment,and the status epilepticus and intracranial lesions during the disease,epileptic discharge before stopping drug,no-attack time less than 4 years before reducing and stopping drug,high epilepsy relapse rate after stopping drug in patients with reducing drug time less than 6 months were found(P < 0.05 to P < 0.01).Multivariate logistic regression analysis showed that the epileptic seizure more than 5 times 1 year,duration more than 1 year before treatment,intracranial lesions,epileptic discharge before stopping drug,no-attack time less than 4 years before stopping and reducing drug time less,and reducing drug time less than 6 months were the high risk factors of epilepsy relapse(OR=2.976 to 8.742,P<0.05).Conclusions:The risk factors of the epilepsy recurrence in patients treated with monotherapy after stopping drug are more,taking appropriate intervention measures can reduce the recurrence of epilepsy.