Clinical effect of Irbesartan in the treatment of essential hypertension complicated with left ventricular hypertrophy

Objective:To explore the clinical effects of Irbesartan in the treatment of essential hypertension complicated with left ventricular hypertrophy.Methods:One hundred and five patients with essential hypertension complicated with left ventricular hypertrophy were randomly divided into the control group and treatment group.The control group were treated with Benazepril hydrochloride by oral,10 mg/d for 6 months,and the treatment group were treated with Irbesartan by oral,150 mg/d for 6 months.The blood pressure,left ventricular end-diastolic interventricular septum thickness(LVST),left ventricular end-diastolic wall thickness(LVPWT),left ventricular end-diastolic cavity diameter(LVED),left ventricular ejection fraction(LVEF)and other cardiac function and clinical efficacy before and after treatment between two groups were compared.Results:Compared with before treatment,the blood pressure,LVST,LVPWT and LVED in two groups significantly decreased after 6 months of treatment(P<0.05),and the decreasing degrees of whose in treatment group were significantly more than those in control group after treatment(P<0.05).The LVEF in treatment group after treatment was significantly higher than that in treatment group before treatment and control group after treatment(P<0.05).The difference of clinical efficacy between two groups was no statistically significant(P<0.05).Conclusions:Both Irbesartan and Benazepril can effectively reduce the blood pressure,reverse left ventricular hypertrophy and improve left ventricular diastolic function,and the treatment efffect of Irbesartan is more significant.