The correlative analysis of the olfactory dysfunction in patients with early stage Parkinson's disease

Objective:To detect the olfactory dyfunction condition in patients with early stage Parkinson's disease,and explore the significance of the quantitative olfactory detection in the early diagnosis of PD.Methods:The bilateral nasal olfactory in 45 patients with early stage PD and 49 healthy examinees at the same time were examined using the "five odors olfactory detection arrays".The relationships between the age,disease duration,UPDRS score and Hoehn-Yahr staging,and olfactory were analyzed in patients with PD.Results:The detection threshold and identification threshold of olfactory in patients with Parkinson's disease were significantly higher than those in healthy people(P<0.01).The detection threshold and identification threshold of olfactory were not signficantly correlated with the age,course of disease,UPDRS score and Hoehn-Yahr staging of patients(P>0.05),and the UPDRS score was positively correlated with the disease duration and H-Y staging(P<0.01 and P<0.05).Conclusions:The olfactory dysfunction in patients with early stage PD is found,and bilateral symmetry.The olfactory detection has certain significance in the early diagnosis of PD.