Effect of celecoxib in the treatment of sepsis and its possible mechanism

Objective:To observe the curative effect of celecoxib in sepsis patients,and explore its possible mechanism.Methods:Fifty-two patients with sepsis were randomly divided into the observation group(28 cases treated with celecoxib) and control group(24 cases treated with traditional method) from March 2010 to November 2014.The data of the general information,the correlated indicators of efficacy and prognosis,and the indicators of infection,inflammation and T cell subsets before and after treatment between two groups were analyzed and compared.Results:The total length of hospital stay and APACHE Ⅱ score in observation group were lower than those in control group after 1 week of treatment(P<0.01).The differences of the indexes of infection,inflammation and T cell subsets before treatment between two groups were not statistically significant(P>0.05),but the levels of WBC,PCT,CRP,TNF-α,IL-1β and IL-6 in observation group were obviously lower than those in control group after 1 week of treatment(P<0.01).After 1 week of treatment,the levels of CD4⁺ and CD4⁺/CD8⁺ T cells in observation group were significantly higher than those in control group,and the level of CD8⁺ T cells in observation group was lower than that in control group(P<0.01).Conclusions:Celecoxib can significantly inhibit the inflammatory reaction,and improve the immunologic function of T lymphocytes and prognosis of patients with sepsis.