The correlation between the catestatin level and prognosis of patients with chronic heart failure

Objective:To explore the correlation between the catestatin(CST) level and prognosis of patients with chronic heart failure(CHF).Methods:The general information and associated clinical data of 97 patients with CHF were collected,and 50 healthy people were set as the control at the same time.The relationships between the CST level,heart function classification and left ventricular ejection fraction(LVEF) in CHF patients were analyzed.All patients were followed up for 2 years.The ROC curves of CST level and recurrence of cardiovascular event within 2 years were drew.The patients were divided into the recurrence of cardiovascular event group and non-event group according to the occurrence of the cardiovascular event.The risk factors of the occurrence of the cardiovascular event were analyzed in CHF patients.Results:The level of CST in CHF patients was significantly higher than that in healthy people(P<0.01).The heart function classification and LVEF level were positively and negatively related to the CST level in CHF patients,respectively(P<0.01).Within 2 years of the following up,miss following up in 5 cases,recurrence of heart failure and hospitalization in 27 cases,and death in 4 cases were identified.On the basis of the ROC curve,the value of CST level(0.75 ng/mL) in predicting the recurrence of the cardiovascular event was higher in CHF patients,the sensitivity and specificity of which were 96.8% and 85.2%,respectively.Logistic regression analysis showed that the age increasing,LVEF decreasing and CST increasing were the independent risk factor of the reoccurrence of cardiovascular events in patients with CHF(P<0.01 to P<0.05).Conclusions:The CST level is related to the severity of disease in CHF patients,which has definite value in evaluating the prognosis of patients with CHF.