Study on flurbiprofen,dezocine and flurbiprofen combined with dezocine in relieving postoperative hyperalgesia induced by remifentanil

Objective:To investigate the effects of flurbiprofen,dezocine,flurbiprofen combined with dezocine on relieving postoperative hyperalgesia induced by remifentanil.Methods:One hundred and twenty patients scheduled by laparoscopic surgery were anesthesized using conventional remifentanil.The patients with ASA grade Ⅰto Ⅱ were divided into group F,group D and group F combined with D using random number method(40 cases each group).The group F was treated with 2 mg/kg of flurbiprofen axetil before anesthesia,and same volume of 0.9% NaCl injection before 30 min of the end of operation.The group D was treated with the same volume of 0.9% NaCl injection before anesthesia,and 0.2 mg/kg of dezocine before 30 min of the end of operation.The group D combined with F was treated with 1 mg/kg of flurbiprofen axetil before anesthesia,and 0.1 mg/kg of dezocine before 30 min of the end of operation.The mean arterial pressure and heart rate in three groups were observed and recorded at the end of sewing skin(T₁),extubating laryngeal mask(T₂) and 30 min after extubating laryngeal mask(T₃).The incidence rates of nausea,vomiting,dizziness and somnolence,and VAS score in three groups were recorded.Results:The differences of the levels of the mean arterial pressure and heart rate at T₁,T₂ and T₃ between three groups were not statistically significant(P>0.05).The differences of the incidence rates of nausea,vomiting,dizziness and somnolence after operation between three groups were statistically significant(P<0.01).Compared with group D and group F combined with D,the incidence rates of postoperative nausea and vomiting in group F significantly increased(P<0.01).Compared with group F and group F combined with D,the incidence rates of postoperative dizziness and somnolence in D group significantly increased(P<0.01).During the postoperative recovery period,the differences of the VAS scores between three groups were statistical significance(P<0.01),the differences of the VAS scores between group F combined with D and group F,and between group F combined with D and group D were statistically significant(P<0.01),and the difference of the VAS score between group F and group D was not statistically significant(P>0.05).Conclusions:The effect of flurbiprofen combined with dezocine on relieving postoperative hyperalgesia induced by remifentanil is better than that of flurbiprofen or dezocine.