Correlation between the serum levels of fibrinogen,D-dimer,C-reactive protein and uric acid,and acute cerebral infarction

Objective: To investigate the relationships between the serum levels of fibrinogen(Fib),D-dimer(D-D),C-reactive protein (CRP) and uric acid(UA),and acute cerebral infarction(ACI).Methods: Fifty-five ACI patients from February 2015 to November 2016 were divided into the ACI group,and subdivided into the mild group(18 cases),medium group(26 cases) and severe group(11 cases) according to the score of the clinical nerve function defect.Fifty-five healthy people were set as the control group.The levels of Fib,D-D,CRP and UA were detected,and the correlations between the serum levels of Fib,D-D,CRP and UA,and degree of nerve function defect were analyzed.Results: The serum levels of Fib,D-D and CRP in ACI group were significantly higher than those in control group(P<0.01),and there was no statistical significance in the difference of UA level between the ACI group and control group(P>0.05).With the aggravating of the degree of nerve function defect,the levels of the Fib,D-D and CRP gradually increased in ACI group(P<0.05 to P<0.01).There was no statistical significance in serum UA level among the ACI patients(P>0.05).Conclusions: The degree of never function defect is related to the levels of Fib,D-D and CRP in ACI patients,which has guiding significance in the diagnosis and treatment of ACI.The UA level is not obviously related to ACI.