Effect of the intensive treatment with atorvastatin calcium before operation on the myocardial markers and inflammatory factors in patients with coronary heart disease after percutaneous coronary intervention

Objective: To explore the effects of the treatment with atorvastatin calcium before operation on the myocardial markers and inflammatory factors in patients with coronary heart disease after percutaneous coronary intervention(PCI).Methods: One hundred and fifty coronary heart disease patients scheduled by PCI were randomly divided into group A,B and C(50 cases each group).Group A,B and C were treated with 20,40 and 60 mg of atorvastatin calcium before PCI,respectively.The levels of CTnI,CK-MB,hs-CRP,NO and ET in 3 groups were detected after 3 days of operation,and the adverse heart events within the postoperative 30 days were observed.Results: Compared with before operation,the levels of CTnI and CK-MB in 3 groups significantly increased 3 days after PCI(P<0.05 to P<0.0),and the levels of myocardial markers in group A and group B closely arrived at the normal levels compared with group C(P<0.05).Compared with before operation,the levels of hs-CRP and ET in 3 groups significantly decreased 3 days after PCI(P<0.01),and the decreasing degree of which in group C was more obvious compared with group A and group B(P<0.05 to P<0.01).Compared with before operation,the levels of NO in 3 groups significantly increased 3 days after PCI(P<0.01),and the increasing degree of which in group C was more obvious compared with group A and group B(P<0.05 to P<0.01).The incidence rate of adverse heart event in group C(2.2%) was significantly lower than that in group A(22.0%) and group B(10.0%) (P<0.01).Conclusions: The application of 60 mg/d of atorvastatin calcium in coronary heart disease patients scheduled by PCI can significantly reduce the myocardial injury,inflammation reaction and postoperative adverse heart events,and which is safe and worthy of promotion and application.