Relationship between the levels of hs-CRP,CysC,ApoA,Lp (a) and GRACE score in NEST-ACS patients

Objective: To investigate the correlations between serum high-sensitivity C-reactive protein(hs-CRP),Cystatin C(CysC),apolipoprotein A(ApoA),lipoprotein(a)Lp(a) and global registry of acute coronary evects(GRACE) score in non ST-elevation acute coronary syndromes(NSTE-ACS) patients. Methods: One hundred and thirty patients with NSTE-ACS and 80 patients without NSTE-ACS were divided into the NSTE-ACS group and control group,respectively.The clinical data of patients were collected,the serum levels of hs-CRP,CysC,ApoA and Lp(a) were detected on the second day of admission,and the GRACE score was assessed.The NSTE-ACS patients were subdivided into the low risk group(GRACE score ≤ 99),middle risk group(140 ≥ GRACE score>99) and high risk group(GRACE score>140) according to the GRACE risk score. Results: The age,gender,creatinine,history of hypertension and diabetes,hs-CRP,Lp(a),CysC and GRACE score in NSTE-ACS group were higher than those in control group (P<0.05 to P<0.01),while the level of ApoA in NSTE-ACS group was significantly lower than that in control group(P<0.01).The differences of the coronary artery lesion between three groups were not statistically significant(P>0.05),while the differences of the coronary artery stenosis degree between three groups were statistically significant(P<0.05).The serum levels of hs-CRP and Lp(a) in middle risk group and high risk group were significantly higher than those in low risk group(P<0.01),but the serum levels of ApoA in middle risk group and high risk group were significantly lower than those in low risk group(P<0.01).The serum levels of Lp(a) and CysC in high risk group were significantly higher than those in middle risk group(P<0.01),the serum level of ApoA in high risk group was significantly lower than that in middle risk group(P<0.01),and the serum level of CysC in high risk group was significantly higherthan that in low risk group(P<0.01).The differences of the levels of hs-CRP,ApoA,Lp(a) and CysC in different coronary artery lesions and stenosis degrees were statistically significant(P<0.01).In three-vessel coronary artery lesions and severe stenosis or occlusion of coronary artery patients,the levels of hs-CRP,Lp(a) and CysC were the highest,and the level of ApoA was the lowest.In single-vessel coronary artery lesion and mild stenosis of coronary artery patients,the levels of hs-CRP,Lp(a) and CysC were the lowest,and the level of ApoA was the highest. Conclusions: The levels of hs-CRP,CysC,Lp(a) and ApoA are closely related to the GRACE score.The joint detection has important clinical reference values in the early risk stratification,prognosis assessment and diagnosis scheme.