• 中国科技论文统计源期刊
  • 中国科技核心期刊
  • 中国高校优秀期刊
  • 安徽省优秀科技期刊
ZHANG Hai-hong, WEN Yun. The clinical value of serum procalsitonin in anti-infection treatment for acute exacerbation of chronic obstructive pulmonary disease[J]. Journal of Bengbu Medical University, 2017, 42(6): 732-735. DOI: 10.13898/j.cnki.issn.1000-2200.2017.06.010
Citation: ZHANG Hai-hong, WEN Yun. The clinical value of serum procalsitonin in anti-infection treatment for acute exacerbation of chronic obstructive pulmonary disease[J]. Journal of Bengbu Medical University, 2017, 42(6): 732-735. DOI: 10.13898/j.cnki.issn.1000-2200.2017.06.010

The clinical value of serum procalsitonin in anti-infection treatment for acute exacerbation of chronic obstructive pulmonary disease

More Information
  • Received Date: August 29, 2016
  • Objective: To explore the clinical value of serum procalsitonin(PCT) level in anti-infection treatment for acute exacerbation of chronic obstructive pulmonary disease(AECOPD). Methods: One hundred and twenty patients with AECOPD were divided into the PCT group and conventional group according to the random number table(60 cases each group).The use of antibiotics in PCT group was adjusted according to the serum level of PCT(PCT ≥ 0.25 μg/L,use antibiotics,and PCT<0.25 μg/L,not use antibiotics),and the use of antibiotics in conventional group was adjusted according to the clinical symptoms of patients and clinical experience of doctors.The rate of antibiotics use,length of antibiotics use,length of hospital stay,clinical effective rate,double infection rate,recurrence rate within half a year,inflammatory indicators[including white blood cells(WBC),neutrophils,C-reactive protein (CRP)] and blood gas index were observed in two groups. Results: The rates of antibiotics use and double infection in PCT group were significantly lower than those in conventional group(P<0.01 and P<0.05),and the length of antibiotics use in PCT group was significantly shorter than that in the conventional group(P<0.01).Compared with the conventional group,the length of hospital stay in PCT group was significantly shorter(P<0.01).There were no statistical significances in clinical effective rate and recurrence rate within half a year between two groups(P>0.05).After treatment,there were no statistical significances in WBC count,neutrophils level,serum CRP level and blood gas index between two groups(P>0.05). Conclusions: According to the serum PCT level in anti-infection therapy of AECOPD patients,the antibiotics use can be effectively reduced,the length of hospitalization can be shortened,the double infection rate can be decreased,and the therapeutic effect can not be affected.
  • [1]
    慢性阻塞性肺疾病急性加重(AECOPD)诊治专家组.慢性阻塞性肺疾病急性加重(AECOPD)诊治中国专家共识(2014年修订版)[J].国际呼吸杂志,2014,34(1):1.
    [2]
    黄小芬.降钙素原和C-反应蛋白在慢性阻塞性肺疾病急性加重期中的应用价值[J].临床医药文献杂志,2016,13(2):362.
    [3]
    中华医学会呼吸病学分会慢性阻塞性肺疾病学组.慢性阻塞性肺疾病诊治指南(2013年修订版)[J].中华结核和呼吸杂志,2013,36(4):255.
    [4]
    CHRIST-CRAIN M,JACCARD-STOLZ D,BINGISSER R, et al.Effect of procalcitonin-guided treatment on antibiotic use and outcome inlower respiratory tract infections:cluster-randomised,singie-blinded intervention trial[J].Lancet,2004,363(9409):600.
    [5]
    尚辉辉,赵亚群.支气管灌洗在AECOPD治疗中的疗效[J].临床肺科杂志,2011,16(11):1776.
    [7]
    LINDENAUER PK,SHIEH MS,PEKOW PS, et al.Use and outcomes associated with long-acting bronchodilators among patients hospitalized for chronic obstructive pulmonary disease[J].Ann Am Thorac Soc,2014,11(8):1186.
    [8]
    顾宇彤.诊断慢性阻塞性肺疾病急性加重期的生物标志物 P[J].中华结核和呼吸杂志,2014,37(4):247.
    [9]
    黎艳聪,舒啸.血清降钙素原对于慢性阻塞性肺疾病急性加重病人的临床意义[J].国际呼吸杂志,2013,33(5):345.
    [10]
    韩从华.降钙素原和炎性反应因子COPD急性加重期诱因鉴别中的应用[J].临床合理用药,2016,9(5A):130.
    [11]
    BRESSAN S,ANDREOLA B,CATTELAN F, et al.Predicting severe bacterial infections in well-appearing febrile neonates:laboratory markers accuracy and duration of fever[J].Pediatr Infect Dis,2010,29(3):227.
    [12]
    赖连娣,安良敏,陈怡.降钙素原在慢性阻塞性肺疾病急性加重期的应用价值[J].中国医学工程,2014,22(8):44.
    [13]
    刘盛盛,张妍蓓.血清降钙素原水平对慢性阻塞性肺疾病急性加重期抗生素使用的指导价值[J].中国抗生素杂志,2015,40(6):459.
    [14]
    巫天贤,金雪文,张叶辉,等.降钙素原在慢性阻塞性肺疾病急性加重期指导抗生素使用的价值[J].温州医科大学学报,2016,46(4):292.

Catalog

    Article views (3153) PDF downloads (100) Cited by()

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return