Assessment of clinical efficacy of mosapride combined with rabeprazole sodium enteric-coated tablet in the treatment of senile reflux esophagitis

Objective: To investigate the clinical effects of mosapride combined with rabeprazole sodium enteric-coated tablet in the treatment of senile reflux esophagitis(RE). Methods: Seventy-eight elderly patients with RE were randomly divided into the control group and observation group(39 cases each group).The control group was treated with 20 mg of rabeprazole sodium enteric-coated tablet each time,one tablet a day,and the observation group was treated with 5 mg of mosapride each time,3 times a day,based on the control group for 8 weeks.The serum levels of gastrointestinal hormonesgastrin(GAS),motilin(MTL) and vasoactive intestinal peptide(VIP) and cytokines,and 24 h pH value of esophagus were measured,and the score of typical RE symptom was evaluated.The clinical effect between two groups was compared. Results: Compared with before treatment,the serum levels of GAS and MTL in two groups increased (P<0.01),and the serum levels of VIP,IL-6,IL-8 and TNF-α in two groups decreased after treatment(P<0.01).Compared with before treatment,the number of reflux(pH<4),reflux frequency(reflux duration ≥ 5 min),longest reflux duration time(pH<4),total time(pH<4)and percentage of time(pH<4) in two groups decreased after treatment(P<0.01).Compared with before treatment,the scores of the typical RE symptoms(heartburn,acid reflux and retrosternal burning pain) in two groups decreased after treatment(P<0.01).Compared with the control group,the levels of MTL and GAS in observation group were higher(P<0.01),the levels of VIP,IL-6,IL-8 and TNF-α in observation group were lower(P<0.01).Compared with the control group,the number of reflux(pH<4) and reflux frequency(reflux duration ≥ 5 min),longest reflux duration time(pH<4),total time(pH<4)and percentage of time(pH<4) in observation group were lower(P<0.01).Compared with the control group,the scores of the typical RE symptoms(heartburn,acid reflux,substernal burning pain) in observation group were lower(P<0.01),and the total effective rate in observation group was higher(P<0.05). Conclusions: The clinical effect of mosapride combined with rabeprazole sodium enteric-coated tablet in the treatment of senile RE is good,which may be associated with the regulation of factrs such as MTL,IL-6, TNF-α and so on.