Correlation analysis between serum cystatin C and glomerular filtration rate in patients with chronic kidney disease

Objective: To investigate the correlation between serum cystatin C(Cyst C) and glomerular filtration rate(GFR) in patients with chronic kidney disease(CKD),and explore the clinical value of serum Cyst C. Methods: The levels of serum Cyst C and creatinine(Scr) in 82 CKD patients were detected,the GFR_Inulin was detected by inulin clearance rate,and the GFR_MDRD and GFR_C-G were calculated using the simplified equations of MDRD and C-G.The GFR_Inulin was set as the standard value of GFR of CKD patients,the correlation between each parameter in different CKD stage patients was compared. Results: The level of Cyst C was negatively correlated with GFR_Inulin in CKD stage 1,2 and 3 patients(P<0.05 to P<0.01),and there was not obvious correlations between the level of Cyst C and GFR_Inulin in CKD stage 4 and 5 patients(P>0.05).There were correlations between the serum levels of Scr,GFR_MDRD and GFR_C-G,and GFR_Inulin in CKD stage 3 patients(P<0.01).In CKD stage 1 patients,the sensitivity and specificity of Cyst C were significantly higher than those of GFR_MDRD and GFR_C-G. Conclusions: The serum Cyst C can be acted as an index in evaluating GFR of CKD patients,and its clinical value is greater especially in early CKD.