The correlation between ApoE allele _ε4 carrier and blood lipid level in elders in Ningxia

Objective:To analyze the correlation between the apolipoprotein E(ApoE) gene polymorphism and blood lipid in elders.Methods:Nine hundred and twenty-four elders aged over 55 years old were selected using typical sampling method.The cases were investigated using a questionnaire,and the blood lipid indicators were examined.The ApoE gene polymorphism was detected using the high resolution melting(HRM) curve method.The correlation between ApoE gene polymorphism and blood lipid was analyzed using ANOVA.Results:The differences of the levels of TG,HDL-C,ApoA,BMI and glucose in all cases were statistically significant(P<0.05).The proportion of E3 in all allele frequency distribution was the largest.The differences of the genotype distribution,allele frequency distribution and carry E4 frequency distribution among all cases were statistically significant(P<0.05).After the age and gender were controlled,the genotype was correlation with the HDL-C,LDL-C,ApoA and ApoB(P<0.05 to P<0.01).Conclusions:The blood lipid level is associated with age,and the ApoE4 carriers is significant associated with the blood lipid level of the elders in Ningxia.