Curative effect of the GP combined with thalidomide in the treatment of advanced triple-negative breast cancer

Objective:To explore the curative effects and adverse reactions of GP combined with thalidomide in the treatment of advanced triple-negative breast cancer.Methods:A total of 58 patients with advanced triple-negative breast cancer were randomly divided into the GP combined with thalidomide group(combination group) and GP group(chemotherapy group)(29 cases each group).The curative effect,adverse reaction,tumor marker and median survival time(MST) between two groups were compared.Results:The effective rate in combination group(58.62%) was higher than that in chemothreapy group(31.03%)(P<0.05).The MST in combination group(37 months) was higher than that in chemothreapy group(32 months)(P<0.05).The decline rate of tumor markers in combination group(65.51%) was higher than that in chemothreapy group(37.93%)(P<0.05).The gastrointestinal reaction rate in combination group(13.79%) was lower than that in chemothreapy group(41.38%)(P<0.05).The difference of the incidence rates of the bone marrow depression and constipation between two groups were not statistically significant(P>0.05),other adverse rections were not obvious.Conclusions:GP combined with thalidomide in treating advanced triple-negative breast cancer is good curative effect and mild adverse reactions,which is worthy of promotion.