Effect of sufentanil anesthesia on craniocerebral injury patients treated with operation

Objective:To study the effects of sufentanil anesthesia on craniocerebral injury patients treated with operation.Methods:Seventy-eight patients scheduled by craniotomy were randomly divided into the observation group and control group(39 cases each group).The control group and observation group were anaesthetized by remifentanil and sufentanil,respectively.The heart rate(HR),blood pressure,and levels of blood epinephrine(AD),noradrenaline(NE) and cortisol(CORT) between two groups were compared before induction anesthesia(T₀),during nasotracheal intubation(T₁),after 3 and 5 min of extubation(T₂ and T₃),and during extubation(T₄).The breathing recovery time,opening eye time,conscious time,extubation time and extubation reaction after operation in two groups were recorded.Results:Hemodynamics:compared with T₀,the levels of systolic pressure(SBP),diastolic pressure(DBP),HR and oxygen saturation(SpO₂) in two groups significantly decreased at T₁,T₂,T₃ and T₄(P<0.01).The levels of SBP and HR in observation group at T₁,T₂,T₃ and T₄ were significantly higher than those in control group(P<0.01),the levels of DBP in observation group at T₁,and T₂ and T₄ were lower and higher than that in control group,respectively(P<0.01),and the difference of the level of DBP at T₃ between two groups was not statistically significant(P>0.05).The levels of SpO₂ in observation group at T₂ and T₄ were higher than that in control group(P<0.01),and the difference of the level of SpO₂ at T₃ between two groups was not statistically significant(P>0.05).Blood index detection:compared with T₀,the levels of AD,NE and CORT in control group significantly increased at T₁,T₂ and T₃(P<0.01),and the differences of the levels of AD,NE and CORT in observation group between all time-points were not statistically significant(P>0.05).The levels of AD,NE and CORT in observation group at T₁,T₂ and T₃ were significantly lower than those in control group(P<0.01).Postoperative observation:the spontaneous breathing recovery time,opening eye time,conscious time and extubation time in observation group were significantly longer than those in control group(P<0.01),and the extubation reaction rate in observation group was lower than that in control group(P<0.05).Conclusions:Compared with remifentanil,the sufentanil anesthesia can reduce cardiovascular stimulation,and the intraoperative and postoperative extubation stress reaction in craniocerebral injury patients treated with operation.