Study on the relationship between homocysteine level and short-term outcome in acute cerebral infarction patients

Objective:To study the correlation between homocysteine(Hcy) level and acute cerebral infarction.Methods:One hundred and twenty patients with acute cerebral infarction patients were detected using the carotid color ultrasonography,and the Hcy levels and blood routine biochemical indexes in all cases were examined.The patients were divided into two groups according to the degree of vascular stenosis,TOAST classification and carotid atherosclerosis plaque.The correlations between the degree of intracranial artery stenosis,carotid atherosclerosis plaque and cerebral infarction type,and Hcy levels were compared.The never function of the patients was evaluated using the modified Rankin scale(mRS),and the cardiovascular and cerebrovascular events and correlation between mRS score and Hcy level in all cases were analyzed.Results:The level rate of Hcy in non-stenosis group was significantly lower than that in stenosis group(P<0.01),and the difference of the incidence rate in different degree stenosis patients was statistically significant(P<0.01).The level of high homocysteine(HHcy) and Hcy in non-stenosis group were significantly lower than those in stenosis group(P<0.01).The differences of the incidence rates in large-artery atherosclerosis(LAA),cardiogenic cerebral embolism(CE),small arterial occlusive or lacunar stroke(SAA),stroke of other demonstrated etiology(SOE) and stroke of other undermonstrated etiology(SUE) groups were not statistically significant(P>0.05),the difference of the value of Hcy in each group was statistically significant(P<0.01),and the level of Hcy in LAA group was higher than that in CE,SAA,SUE and SOE groups(P<0.05 to P<0.01).The total incidence rate of the cardiovascular event in HHcy group was higher than that in normal Hcy group(P<0.05),and the mRS score in HHcy group was significantly higher than that in normal Hcy group(P<0.01).Conclusions:The intracranial artery stenosis severity,TOAST classification and carotid atherosclerosis plaque are related to the blood Hcy.The HHcy is an important factor leading to the poor prognosis of patients with acute cerebral infarction.