Diagnostic Value of 3.0TMRI Apparent Diffusion Coefficient in Prostate Cancer and Its Correlation with Prognostic Factors

Objective:To investigate the value of 3.0T MRI apparent diffusion coefficient (ADC) in the diagnosis of prostate cancer,and its correlation with pathologic Gleason score and prostate specific antigen (PSA).Methods:The clinical data of 52 patients with prostate disease confirmed by pathology from August 2015 to March 2017 were retrospectively analyzed,including 22 cases of prostate cancer (PCa) and 30 cases of benign prostatic hyperplasia (BPH).So patients were routine MRI scan,b = 0,800 s / mm2 to establish the ADC and ADC lesions measured,according to the ADC value to identify the diagnosis of PCa and BPH.And to assess its association with pathologic Gleason score and PSA.Results:The average ADC of 52 patients with prostate disease was (1.028±0.310)×10^-3 mm²/s,PCa patients and BPH patients with ADC average significant difference,respectively (0.788±0.204)×10^-3mm²/s and (1.204±0.251)×10^-3mm²/s.The area under the ROC curve of the ADC value is 0.903,which has a good diagnostic effect.According to the ROC curve to determine the ADC value of the best diagnostic value of 0.831,the sensitivity of 72.7%,specificity of 100.0%.There was a negative correlation between the ADC value and the PSA(r=-0.519,P<0.01),and the ADC value was negatively correlated with the Glseason score(r=-0.508,P<0.01).Conclusions:The quantitative evaluation of ADC value is valuable for the identification of benign and malignant benign prostatic lesions.The low risk and high risk prostate cancer can be used to evaluate the clinical stage of PCa and guide the clinical selection of appropriate treatment Program.