Effect of repetitive transcranial magnetic stimulation combined with galantamine in the treatment of Alzheimer's disease

Objective:To evaluate the effects of repetitive transcranial magnetic stimulation(rTMS) combined with galantamine in the treatment of Alzheimer's disease(AD).Methods:Forty-three AD patients were randomly divided into the galantamine group(21 cases) and galantamine + rTMS group(22 cases).The scores of simple intelligent state scale(MMSE),clinical dementia scale(CDR),daily life ability scale(ADL) in two groups were evaluated before and after treatment.Results:The difference of the total effective rate between two groups after 6 months of treatment was not statistically significant(P>0.05).The differences of the scores of MMSE,ADL and CDR between two groups before treatment were not statistically significant(P>0.05).After 6 months of treatment,the MMSE scores increased(P<0.05),and the scores of ADL and CDR decreased in two groups(P<0.01).After 6 months of treatment,the MMSE score in galantamine group was lower than that in galantamine + rTMS group at the same point(P<0.01),and the scores of ADL and CDR in galantamine group were higher than those in galantamine+rTMS group(P<0.01).The differences of the incubation of N1,N2 and P3 between double sides high frequency and right side high frequency complicated with left side low frequency groups before treatment were not statistically significant(P>0.05).The wave amplitude of N1,N2 and P3 before and after treatment had no significant change in two groups(P>0.05),the incubation of P3 wave shorten after treatment(P<0.01).Compared with the right side high frequency complicated with left side low frequency group,the incubation of P3 in double sides high frequency group significantly shorten after treatment(P<0.01).Conclusions:The total effective rate of rTMS combined with galantamine in the treatment of AD is higher than that of galantamine.The scores of MMSE,ADL and RAD show that the clinical effect of rTMS combined with galantamine in the treatment of AD is better than that of galantamine.