Significance of the serum cystatin C,microdose albumin and β₂-microglobulin detection in the diagnosis and prognosis of the acute kidney injury

Objective:To investigate the significance of the serum cystatin C(CysC),microdose albumin(mAlb) and β₂-microglobulin(β₂-MG) detection in the diagnosis and prognosis of the acute kidney injury(AKI).Methods:Ninety-seven AKI patients were divided into the stage AKI 1(45 cases),stage AKI 2(27 cases) and stage AKI 3(25 cases),and 55 healthy people were set as the control group.The levels of CysC,mAlb and β₂-MG were detected in each group,and the scores of acute physiology and chronic health evaluation Ⅱ (APACHEⅡ) in all cases were evaluated.Results:The differences of the serum levels of CysC,mAlb and urine β₂-MG between fours groups were statistically significant(P<0.01),the levels of CysC,mAlb and urine β₂-MG in AKI groups were significantly higher than those in control group(P<0.01),the levels of CysC,mAlb and urine β₂-MG in AKI 2 and AKI 3 groups were significantly higher than those in AKI 1 group(P<0.01),and the levels of CysC,mAlb and urine β₂-MG in AKI 3 groups were significantly higher than those in AKI 2 group(P<0.01).The differences of the scores of APACHEⅡ between four groups were statistically significant(P<0.01),the scores of APACHEⅡ in AKI 2 and AKI 3 groups were significantly higher than those in AKI 1 group(P<0.01),and the score of APACHEⅡ in AKI 3 group was significantly higher than that in AKI 2 group(P<0.01).The levels of serum CysC,mAlb and urine β₂-MG were significantly positive correlated with APACHEⅡ score(P<0.01).The positive rate of the combined detection of serum CysC,mAlb and β₂-MG in the diagnosis of AKI was significantly higher than that of the independent 3 indicator(P<0.05).The levels of serum CysC,mAlb,urine β₂-MG and APACHEⅡ score in survival cases were significantly lower than those in death cases(P<0.01).Conclusions:The serum CysC,mAlb and urine β₂-MG are closely related to the severity and prognosis of AKI patients,which can be used as an important indicator in evaluating the severity and prognosis of AKI patients.