Effect of butylphthalide on early cardiopulmonary resuscitation in asphyxia cardiac arrest rats

Objective: To investigate the effects of butylphthalide on early cardiopulmonary resuscitation in asphyxia cardiac arrest rats.Methods: Fifteen healthy SD rats were divided into the sham group,cardiopulmonary resuscitation group and butylphthalide intervention group using random number table method(5 rats each group).The hemodynamic parameters were monitored,the inflammatory factors were detected suing immunohistochemistry,and the correlate factors were detected using flow cytometry.Results: After spontaneous circulation recovery in 3 groups,with the time passing,the heart rate and mean arterial pressure gradually increased(P<0.05 to P<0.01).The increasing degrees of the heart rate and mean arterial pressure in butylphthalide intervention group were higher than those in cardiopulmonary resuscitation group,and the increasing degrees of the heart rate and mean arterial pressure in cardiopulmonary resuscitation group were higher than those in sham group(P<0.05 to P<0.01).Compared with before experiment,the levels of the tumor necrosis factor α,interleukin-6 and cell adhesion factor-1 increased(P<0.05),while the levels of interleukin-10 and SOD decreased in three groups at 20min of experiment(P<0.05).At 20min of experiment,the levels of tumor necrosis factor α,interleukin-6 and cell adhesion factor-1 in sham group were more than those in cardiopulmonary resuscitation group,and the levels of tumor necrosis factor α,interleukin-6 and cell adhesion factor-1 in cardiopulmonary resuscitation group were more than those in butylphthalide intervention group(P<0.01).At 20min of experiment,the levels of interleukin-10 and SOD in butylphthalide intervention group were more than those in cardiopulmonary resuscitation group,and the levels of interleukin-10 and SOD in cardiopulmonary resuscitation group were more than those in sham group(P<0.05 to P<0.01).Conclusions: During the early cardiopulmonary resuscitation in asphyxia cardiac arrest rats,the butylphthalide can improve hemodynamics,reduce inflammation reaction,increase SOD activity and inhibit the expression of cell adhesion factor-1.