Expression and significance of FMNL2 and RAC1 in colorectal cancer

Objective:To explore the expressions of FMNL2 and RAC1 in colorectal cancer(CRC) tissues and corresponding precancerous lesions,and correlation of the expressions with clinical pathological parameters.Methods:The mRNA and protein expressions of FMNL2 and RAC1 in CRC tissues and corresponding precancerous lesions were detected by real-time PCR and immunohistochemistry(IHC) method.Results:The mRNA expressions of FMNL2 and RAC1 in CRC tissues were higher than those in corresponding precancerous lesions(P<0.01).The positive rates of FMNL2 and RAC1 in CRC tissues(61.7% and 68.3%) were higher than those in corresponding precancerous lesions(20.8% and 31.7%),respectively(P<0.05).The expressions of FMNL2 and RAC1 were closely related to the tumor metastasis,lymph node metastasis and TNM staging(P<0.05 to P<0.01),but which was not related to the gender and age of patients,and size,differentiation and invasion of tumor(P>0.05).The expression of FMNL2 was positively correlated with RAC1(r=0.495,P<0.05).Conclusions:The expressions of FMNL2 and RAC1 in CRC tissues are high,which is closely related to the tumor metastasis.The combined detection of FMNL2 and RAC1 have important significances in predicting tumor metastasis and prognosis of tumor.