Relationship between CYP2E1 rs3813867 genetic polymorphism and susceptibility of gastric cancer in Hakkaness

Objective:To investigate the correlation between the polymorphisms of CYP2E1 gene single nucleotide rs3813867 and genetic susceptibility of gastric cancer in Hakkaness.Methods:The genotypes and alleles of CYP2E1 rs381386 in 51 gastric cancer patients(gastric cancer group) and 52 healthy people(control group) from Hakkaness in Meizhou area were detected,and the correlation between which and susceptibility of gastric cancer were evaluated.Results:The GG,GC and CC polymorphisms in CYP2E1 rs381386 in Hakkaness in Meizhou were found.The distribution frequency of GG,GC and CC genotypes in gastric cancer group was 62.75%,33.33% and 3.92%,respectively,and that in control group was 59.62%,34.61% and 5.77%,respectively.The distribution frequency of alleles of G and C in gastric cancer group and control group was 79.41% & 20.59% and 76.92% & 23.08%,respectively,and the differences of which between two groups were not statistically significant(P>0.05).The differences of the genotype distribution frequency in different sex and ≥ 60 years old patients between two groups were not statistically significant(P>0.05),and the difference of which in <60 years old patients between two groups was statistically significant(P<0.05).Conclusions:The genetic polymorphisms of CYP2E1 rs3813867 is not significantly correlated with the susceptibility of gastric cancer in Hakkaness.